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Biochim. Biophys. Acta-Rev. Cancer, Sep 17 2023, S0304-419X(23)00137-3 | https://doi.org/10.1016/j.bbcan.2023.188988 The Warburg effect on radioresistance: Survival beyond growth

Hyunkoo Kang ^a,1, Byeongsoo Kim ^a,1, Junhyeong Park ^a, HyeSook Youn ^b, BuHyun Youn ^a,c

^aDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea

^bDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, Republic of Korea

^cDepartment of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea

¹These authors contributed equally.

Corresponding authors: HyeSook Youn, BuHyun Youn

Abstract

The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect. In this review, we focused on the role of the Warburg effect in redox homeostasis and DNA damage repair, two critical factors contributing to radioresistance. In addition, we highlighted the metabolic involvement in the radioresistance of cancer stem cells, which is the root cause of tumor recurrence. Finally, we summarized radiosensitizing drugs that target the Warburg effect. Insights into the molecular mechanisms underlying the Warburg effect and radioresistance can provide valuable information for developing strategies to enhance the efficacy of radiotherapy and provide future directions for successful cancer therapy.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-09-22)
연구진국내 연구진
분야 생명과학 > 노화/암생물학

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