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한빛사논문
한빛사논문
- 조회424
Biomaterials, Sep 04 2023, 302 S0142-9612(23)00323-X | https://doi.org/10.1016/j.biomaterials.2023.122315
Long-term stable wireless smart contact lens for robust digital diabetes diagnosis.
Hye Hyeon Han a, Su-Kyung Kim a, Seong-Jong Kim a, Inhoo Choi a, Jee Won Mok b, Choun-Ki Joo b, Sangbaie Shin c, Sei Kwang Hahn a,c
aDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, South Korea
bDepartment of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 06591, South Korea
cPHI BIOMED Co., #613, 12 Gangnam-daero 65-gil, Seocho-gu, Seoul, 06612, South Korea
Corresponding authors: Hye Hyeon Han, Sei Kwang Hahn
Abstract
Wearable devices for digital continuous glucose monitoring (CGM) have attracted great attention as a new paradigm medical device for diabetes management. However, the relatively inaccurate performance and instability of CGM devices have limited their wide applications in the clinic. Here, we developed hyaluronate (HA) modified Au@Pt bimetallic electrodes for long-term accurate and robust CGM of smart contact lens. After glucose oxidation reaction, the bimetallic electrodes facilitated the rapid decomposition of hydrogen peroxide and charge transfer for robust CGM. The passivation of Au@Pt bimetallic electrode with branch-type thiolated HA prevented the dissolution of Au electrode by chloride ions in tears. In diabetic and normal rabbits, the smart contact lens with HA-Au@Pt bimetallic electrodes enabled the high correlation (ρ = 0.88) CGM with 98.6% clinically acceptable data for 3 weeks. Taken together, we could confirm the feasibility of our smart contact lens for long-term CGM for further clinical development.
논문정보
- Research article
- 2023년 09월 (BRIC 등록일 2023-09-27)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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