한빛사논문 | BRIC

한빛사 논문

조회29

충남대학교

J. Hazard. Mater., Jun 05 2023, 451 S0304-3894(23)00440-5 | https://doi.org/10.1016/j.jhazmat.2023.131158 Engineered tenorite structure of barium-enriched copper oxide for on-site monitoring of cytotoxic methotrexate in environmental samples.

Annamalai Yamuna ^a, Natarajan Karikalan ^a, Dain Lee ^b, Tae Yoon Lee ^a,b

^aDepartment of Biomedical Engineering and Department of Convergence System Engineering, Chungnam National University, Daejeon 34134, Republic of Korea

^bDepartment of Technology Education, Chungnam National University, Daejeon 34134, Republic of Korea

Corresponding author : Tae Yoon Lee

Abstract

Emerging pharmaceutical pollutants pose a threat to both human and environmental health. The removal and monitoring of such pollutants necessitate the use of practical on-site monitoring devices; however, the designs of such devices are underdeveloped. This study involves the fabrication of a low-cost sensor based on barium-incorporated copper oxide (Ba-CuO) for the on-site monitoring of the cytotoxic drug methotrexate (MTRX) in water and sediment samples. The tenorite structure of CuO was slightly enriched with Ba ions at the td sites, distorting the tetrahedron and enhancing its electrochemical properties. Ba-CuO was obtained from Cu(NO ₃) ₂ and Ba(OH) ₂ by a ligand exchange protocol and was characterized using X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray analysis. In addition, the Ba-CuO sensor was tested under various conditions, and it could detect MTRX at concentrations as low as 0.4 nM, with a high sensitivity of 1.3567 µA µM ^-1 cm ^-2. On-site monitoring yielded recoveries of greater than 93 % from spiked samples, thus exhibiting excellent reproducibility and stability. Therefore, the developed method is practical and has no matrix effect on the MTRX sensor.

논문정보

형식Research article
게재일2023년 06월 (BRIC 등록일 2023-09-17)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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