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한빛사 논문

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한국생명공학연구원

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Nano Converg., Sep 16 2023, 10 (1) | https://doi.org/10.1186/s40580-023-00393-3 3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort

Joochan Kim¹, Jaehyung Jeon¹, Hyowon Jang², Youngkwang Moon¹, Abdurhaman Teyib Abafogi¹, Danny van Noort³, Jinkee Lee^1,4, Taejoon Kang^2,5* and Sungsu Park^1,4*

¹School of Mechanical Engineering, Sungkyunkwan University (SKKU), Seobu-ro 2066, Jangan-gu, Suwon 16419, Korea

²Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Gwahak-ro 291, Yuseong-gu, Daejeon 34141, Korea

³Division of Biophysics and Bioengineering, IFM, Linköping University, Linköping 58183, Sweden

⁴Department of Biophysics, Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 16419, Korea

⁵School of Pharmacy, Sungkyunkwan University (SKKU), Suwon 16419, Korea

^*Correspondence: Taejoon Kang, Sungsu Park

Abstract

The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 µL of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-09-17)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

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