서정목 (연세대학교, 링크솔루텍)

한빛사논문

조회317

연세대학교, 링크솔루텍

CV File 311 kb

Adv. Sci., Sep 13 2023, | https://doi.org/10.1002/advs.202303651 A Mechanically Resilient and Tissue-Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care.

Jae Park ^{1 2 †}, Tae Young Kim ^{1 †}, Yeonju Kim ¹, Soohwan An ³, Kyeong Seok Kim ⁴, Minkyong Kang ¹, Soo A Kim ¹, Jayoung Kim ⁵, Joonseok Lee ⁴, Seung-Woo Cho ³, Jungmok Seo ^{1 2 *}

¹School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
²LYNK Solutec Inc., Seoul, 03722, Republic of Korea.
³Department of Biotechnology, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
⁴Department of Chemistry, Hanyang University, Seoul, 04763, Republic of Korea.
⁵Department of Medical Engineering, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.

^†J.P. and T.Y.K. contributed equally to this work.
^*Corresponding author: correspondence to Jungmok Seo

Abstract

Hydrogels are used in wound dressings because of their tissue-like softness and biocompatibility. However, the clinical translation of hydrogels remains challenging because of their long-term stability, water swellability, and poor tissue adhesiveness. Here, tannic acid (TA) is introduced into a double network (DN) hydrogel consisting of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) to realize a tough, self-healable, nonswellable, conformally tissue-adhesive, hemostatic, and antibacterial hydrogel. The TA within the DN hydrogel forms a dynamic network, enabling rapid self-healing (within 5 min) and offering effective energy dissipation for toughness and viscoelasticity. Furthermore, the hydrophobic moieties of TA provide a water-shielding effect, rendering the hydrogel nonswellable. A simple chemical modification to the hydrogel further strengthens its interfacial adhesion with tissues (shear strength of ≈31 kPa). Interestingly, the TA also can serve as an effective hemostatic (blood-clotting index of 58.40 ± 1.5) and antibacterial component, which are required for a successful wound dressing. The antibacterial effects of the hydrogel are tested against Escherichia coli and Staphylococcus aureus. Finally, the hydrogel is prepared in patch form and applied to a mouse model to test in vivo biocompatibility and hemostatic performances.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-09-14)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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