Hanna Cho ^1,2,3, Nidhi S Mundada ¹, Liana G Apostolova ^4,5,6, Maria C Carrillo ⁷, Ranjani Shankar ¹, Alinda N Amuiri ¹, Ehud Zeltzer ¹, Charles C Windon ¹, David N Soleimani-Meigooni ¹, Jeremy A Tanner ¹, Courtney Lawhn Heath ⁸, Orit H Lesman-Segev ^1,9, Paul Aisen ¹⁰, Ani Eloyan ¹¹, Hye Sun Lee ¹², Dustin B Hammers ⁴, Kala Kirby ⁴, Jeffrey L Dage ⁴, Anne Fagan ¹³, Tatiana Foroud ⁶, Lea T Grinberg ^1,14, Clifford R Jack ¹⁵, Joel Kramer ¹, Walter A Kukull ¹⁶, Melissa E Murray ¹⁷, Kelly Nudelman ⁶, Arthur Toga ¹⁸, Prashanthi Vemuri ¹⁵, Alireza Atri ¹⁹, Gregory S Day ²⁰, Ranjan Duara ²¹, Neill R Graff-Radford ²⁰, Lawrence S Honig ²², David T Jones ^15,23, Joseph Masdeu ²⁴, Mario Mendez ²⁵, Erik Musiek ¹³, Chiadi U Onyike ²⁶, Meghan Riddle ²⁷, Emily J Rogalski ²⁸, Stephen Salloway ²⁷, Sharon Sha ²⁹, Raymond Scott Turner ³⁰, Thomas S Wingo ³¹, David A Wolk ³², Robert Koeppe ³³, Leonardo Iaccarino ¹, Bradford C Dickerson ³⁴, Renaud La Joie ¹, Gil D Rabinovici ^1,8; LEADS Consortium ⁴

¹Memory and Aging Center, UCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California, USA.

²Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

³Global Brain Health Institute, University of California, San Francisco, California, USA.

⁴Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

⁵Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.

⁶Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

⁷Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.

⁸Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.

⁹Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel.

¹⁰Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.

¹¹Department of Biostatistics, Center for Statistical Sciences, Brown University, Rhode Island, USA.

¹²Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea.

¹³Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.

¹⁴Department of Pathology, University of California - San Francisco, San Francisco, California, USA.

¹⁵Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

¹⁶Department of Epidemiology, University of Washington, Seattle, Washington, USA.

¹⁷Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

¹⁸Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, California, USA.

¹⁹Banner Sun Health Research Institute, Sun City, Arizona, USA.

²⁰Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.

²¹Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA.

²²Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.

²³Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

²⁴Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA.

²⁵Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

²⁶Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

²⁷Department of Neurology, Alpert Medical School, Brown University, Rhode Island, USA.

²⁸Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

²⁹Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California, USA.

³⁰Department of Neurology, Georgetown University, Washington, USA.

³¹Department of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.

³²Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

³³Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

³⁴Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Hanna Cho and Nidhi S. Mundada contributed equally to this work as first authors

Renaud La Joie and Gil D. Rabinovici contributed equally to this work as last authors

CORRESPONDING AUTHOR : Gil D. Rabinovici