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Cytokine Growth Factor Rev., Aug 23 2023, S1359-6101(23)00055-2 | https://doi.org/10.1016/j.cytogfr.2023.08.008 Multifaceted role of CD14 in innate immunity and tissue homeostasis.

Kunhee Na ^a, Byung-Chul Oh ^a,b,c,1, YunJae Jung^a,c,d,1

^aDepartment of Health Science and Technology, Gachon Advanced Institute for Health Science & Technology, Gachon University, Incheon 21999, the Republic of Korea

^bDepartment of Physiology, College of Medicine, Gachon University, Incheon 21999, the Republic of Korea

^cLee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, the Republic of Korea

^dDepartment of Microbiology, College of Medicine, Gachon University, Incheon 21999, the Republic of Korea

¹These two authors contributed equally to this work.

Correspondence to: Byung-Chul Oh, YunJae Jung

Abstract

CD14 is a co-receptor of Toll-like receptor (TLR)- 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses. In addition to its well-established association with TLR4, CD14 is also implicated in TLR4-independent signaling, which leads to the apoptotic death of differentiated dendritic cells and activation of the noncanonical inflammasome pathway. CD14 also has a role beyond that of the immune responses. It contributes to tissue homeostasis by promoting the clearance of various apoptotic cells via recognizing externalized phosphatidylinositol phosphates. CD14 also has context-dependent roles, particularly in barrier tissues that include the skin and gastrointestinal tract. For example, CD14 ⁺ dendritic cells in the skin can induce immunostimulatory or immunosuppressive responses. In the gastrointestinal system, CD14 is involved in producing inflammatory cytokines in inflammatory bowel disease and maintaining of intestinal integrity. This review focuses on the multifaceted roles of CD14 in innate immunity and its potential regulatory functions in barrier tissues characterized by rapid cell renewal. By providing insights into the diverse functions of CD14, this review offers potential therapeutic implications for this versatile molecule in immune modulation and tissue homeostasis.

논문정보

형식Review Paper
게재일2023년 08월 (BRIC 등록일 2023-09-12)
연구진국내 연구진
분야 의약학 > 면역의학

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