한빛사논문
- 조회409
Ji-Sun Yoo 1 and Sungwhan F. Oh 1,2,*
1Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
2Graduate Program in Immunology, Harvard Medical School, Boston, MA, USA.
*Corresponding author: correspondence to Sungwhan F. Oh
Abstract
The mammalian gut is the most densely colonized organ by microbial species, which are in constant contact with the host throughout life. Hosts have developed multifaceted cellular and molecular mechanisms to distinguish and respond to benign and pathogenic bacteria. In addition to relatively well-characterized innate and adaptive immune cells, a growing body of evidence shows additional important players in gut mucosal immunity. Among them, unconventional immune cells, including innate lymphoid cells (ILCs) and unconventional T cells, are essential for maintaining homeostasis. These cells rapidly respond to bacterial signals and bridge the innate immunity and adaptive immunity in the mucosal barrier. Here, we focus on the types and roles of these immune cells in physiological and pathological conditions as prominent mechanisms by which the host immune system communicates with the gut microbiota in health and diseases.
논문정보
- Review Paper
- 2023년 09월 (BRIC 등록일 2023-09-13)
- 국외 연구진
- 생명과학 > 미생물학
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