박지윤 (분당서울대학교병원, Harvard Medical School)

한빛사논문

조회352

분당서울대학교병원, Harvard Medical School

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EBioMedicine, Volume 95, September 2023, 104780 | https://doi.org/10.1016/j.ebiom.2023.104780 Creating mini-pregnancy models in vitro with clinical perspectives.

Jee Yoon Park ^a,b, Hosub Lim ^b, Jianhua Qin ^c,d,e, Luke P. Lee ^b,f,g

^aDepartment of Obstetrics and Gynecology, Seoul National University, Bundang Hospital, Seoul National University College of Medicine, Republic of Korea

^bDepartment of Medicine, Harvard Medical School, Brigham Women's Hospital, Boston, MA, USA

^cDivision of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

^dInstitute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

^eUniversity of Chinese Academy of Sciences, Beijing, China

^fDepartment of Bioengineering, Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA, USA

^gDepartment of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Korea

Corresponding authors: Jee Yoon Park, Luke P. Lee

Abstract

During the last decade, organs-on-chips or organoids microphysiological analysis platforms (MAP) have garnered attention in the practical applications of disease models, drug discovery, and developmental biology. Research on pregnant women has firm limitations due to ethical issues; thus, remodelling human pregnancy in vitro is highly beneficial for treatment modality development via disease remodelling or drug monitoring. This review highlights current efforts in bioengineering devices to reproduce human pregnancy and emphasises the significant convergence of biology, engineering, and maternal-foetal medicine. First, we review recent achievements in culturing cells from tissues involved in pregnancy; specifically, trophoblasts from the placenta. Second, we highlight developments in the reconstitution of pregnancy-related female reproductive organs across several structural and functional interpretations. Last, we examine research on the fundamental comprehension of pregnancy-associated diseases to find bioengineering solutions. Recreating human pregnancy through an engineered model is naturally complex; nevertheless, challenges are inevitable to progress precision medicine.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-09-12)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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