정인혁 (Washington University School of Medicine)

한빛사논문

조회442

Washington University School of Medicine

CV File 225 kb

Trends Mol. Med , Sep 04 2023, S1471-4914(23)00187-9 | https://doi.org/10.1016/j.molmed.2023.08.002 The emerging Janus face of SVEP1 in development and disease.

Jared S. Elenbaas ^1,2,6, In-Hyuk Jung^1,6, Ariella Coler-Reilly ^2,3, Paul C. Lee ^1,2, Arturo Alisio ¹, Nathan O. Stitziel ^1,4,5

¹Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA

²Medical Scientist Training Program, Washington University School of Medicine, Saint Louis, MO 63110, USA

³Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA

⁴McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO 63108, USA

⁵Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110, USA

⁶These authors contributed equally to this manuscript

Correspondence: Nathan O. Stitziel

Abstract

Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascular development and disease, but its molecular and cellular mechanisms remain poorly defined. Future studies should aim to characterize these mechanisms and determine the diagnostic, prognostic, and therapeutic value of measuring or intervening on this enigmatic protein.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-09-11)
연구진국외 연구진
분야 생명과학 > 분자생물학

댓글 작성 로그인

CV 열람하기

연락처 보기