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Science, Sep 08 2023, 381 (6662) | https://doi.org/10.1126/science.add5649
A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin.
Do-Hyun Kim 1, Yilin Wang 1, Haerin Jung 1, Rachael L Field 1, Xinya Zhang 1, Ta-Chiang Liu 1, Changqing Ma 1, James S Fraser 2, Jonathan R Brestoff 1, Steven J Van Dyken 1,*
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
2Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
*Corresponding author: correspondence to Steven J Van Dyken
Abstract
Dietary fiber improves metabolic health, but host-encoded mechanisms for digesting fibrous polysaccharides are unclear. In this work, we describe a mammalian adaptation to dietary chitin that is coordinated by gastric innate immune activation and acidic mammalian chitinase (AMCase). Chitin consumption causes gastric distension and cytokine production by stomach tuft cells and group 2 innate lymphoid cells (ILC2s) in mice, which drives the expansion of AMCase-expressing zymogenic chief cells that facilitate chitin digestion. Although chitin influences gut microbial composition, ILC2-mediated tissue adaptation and gastrointestinal responses are preserved in germ-free mice. In the absence of AMCase, sustained chitin intake leads to heightened basal type 2 immunity, reduced adiposity, and resistance to obesity. These data define an endogenous metabolic circuit that enables nutrient extraction from an insoluble dietary constituent by enhancing digestive function.
논문정보
- Research article
- 2023년 09월 (BRIC 등록일 2023-09-11)
- 국외 연구진
- 생명과학 > 면역학
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