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Biomaterials, Oct 2023, 301 S0142-9612(23)00295-8 | https://doi.org/10.1016/j.biomaterials.2023.122287 Transplantable stem cell nanobridge scaffolds for accelerating articular cartilage regeneration.

Sunho Park ^a,b,c, Ju Yong Na ^d, Yonghyun Gwon ^a,b,c, Woochan Kim ^a,b,c, Ju Yeon Kang ^d, Jong Keun Seon ^d, Jangho Kim ^a,b,c,e

^aDepartment of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea

^bDepartment of Rural and Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea

^cInterdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju 61186, Republic of Korea

^dDepartment of Orthopedics, Chonnam National University Medical School & Hospital, Hwasun 58128, Republic of Korea

^eInstitute of Nano-Stem Cells Therapeutics, NANOBIOSYSTEM Co., Ltd, Gwangju, Republic of Korea

Corresponding authors: Jong Keun Seon, Jangho Kim

Abstract

Microfracture technique for treating articular cartilage defects usually has poor clinical outcomes due to critical heterogeneity and extremely limited in quality. To improve the effects of current surgical technique (i.e., microfracture technique), we propose the transplantable stem cell nanobridge scaffold, acting as a protective bridge between host tissue and defected cartilage as well as microfracture-derived cells. Nanobridge scaffolds have a sophisticated nanoaligned structure with freestanding and flexible shapes for imposing direct structural guidance to cells including transplanted stem cells and host cells, and it can induce not only chondrocyte migration but also stem cell differentiation, maturation, and growth factor secretion. The transplantable stem cell nanobridge scaffold is capable of reconstructing the defected cartilage with homogeneous architecture and highly enhanced adhesive stress similar with native cartilage tissue by the synergistic effects of stem cells-based chondro-induction and nanotopography-based chondro-conduction. Our findings demonstrate a significant advancement in the traditional treatment technique by using a nanoengineered tool for achieving successful cartilage regeneration.

논문정보

형식Research article
게재일2023년 10월 (BRIC 등록일 2023-09-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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