최진호 (단국대학교)

한빛사논문

조회286

최진호Jin-Ho Choy

단국대학교

Small, Aug 27 2023 | https://doi.org/10.1002/smll.202305148 The Next Generation COVID-19 Antiviral; Niclosamide-Based Inorganic Nanohybrid System Kills SARS-CoV-2.

Goeun Choi ^1,2,3, N Sanoj Rejinold ¹, Huiyan Piao ¹, Young Bae Ryu ⁴, Hyung-Jun Kwon ⁴, In Chul Lee ⁴, Jeong In Seo ⁵, Hye Hyun Yoo ⁵, Geun-Woo Jin ⁶, Jin-Ho Choy ^1,7,8

¹Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116, Republic of Korea.

²College of Science and Technology, Dankook University, Cheonan, 31116, Republic of Korea.

³Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116, Republic of Korea.

⁴Functional Biomaterials Research Center, Korea Research Institute of Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, 34141, Republic of Korea.

⁵Institute of Pharmaceutical Science and Technology, College of Pharmacy, Hanyang University, Ansan, 15588, Republic of Korea.

⁶R&D Center, CnPharm Co. LTD., Seoul, 03759, Republic of Korea.

⁷Department of Pre-Medical Course, College of Medicine, Dankook University, Cheonan, 31116, Republic of Korea.

⁸International Research Frontier Initiative (IRFI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, 226-8503, Japan.

G.C. and N.S.R. contributed equally to this work.

CORRESPONDING AUTHORS : Geun-woo Jin, Jin-Ho Choy

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is a serious global threat with surging new variants of concern. Although global vaccinations have slowed the pandemic, their longevity is still unknown. Therefore, new orally administrable antiviral agents are highly demanded. Among various repurposed drugs, niclosamide (NIC) is the most potential one for various viral diseases such as COVID-19, SARS (severe acute respiratory syndrome), MERS (middle east respiratory syndrome), influenza, RSV (respiratory syncytial virus), etc. Since NIC cannot be effectively absorbed, a required plasma concentration for antiviral potency is hard to maintain, thereby restricting its entry into the infected cells. Such a 60-year-old bioavailability challenging issue has been overcome by engineering with MgO and hydroxypropyl methylcellulose (HPMC), forming hydrophilic NIC-MgO-HPMC, with improved intestinal permeability without altering NIC metabolism as confirmed by parallel artificial membrane permeability assay. The inhibitory effect on SARS-CoV-2 replication is confirmed in the Syrian hamster model to reduce lung injury. Clinical studies reveal that the bioavailability of NIC hybrid drug can go 4 times higher than the intact NIC. The phase II clinical trial shows a dose-dependent bioavailability of NIC from hybrid drug suggesting its potential applicability as a game changer in achieving the much-anticipated endemic phase.

논문정보

형식Research article
게재일2023년 08월 (BRIC 등록일 2023-09-11)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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