한빛사논문
- 조회427
한국표준과학연구원
Eun Sook Lee1, Hyewon Ko2, Chan Ho Kim3, Hyun‑Chul Kim4, Seong‑Kyoon Choi4, Sang Won Jeong4, Se‑Guen Lee4, Sung‑Jun Lee4, Hee‑Kyung Na1, Jae Hyung Park3 and Jung Min Shin4,5*
1 Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong‑Ro, Yuseong‑Gu, Daejeon 34113, Republic of Korea.
2 Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Yuseong‑Gu, Daejeon 34141, Republic of Korea.
3 School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
4 Division of Biotechnology, Convergence Research Institute, DGIST, 333 Techno Jungang‑Daero, Daegu 42988, Republic of Korea.
5 Present Address: Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 27469, Republic of Korea.
Corresponding author : Correspondence to Jung Min Shin.
Abstract
Background: Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy.
Main body: Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges.
Conclusion: This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment.
논문정보
- Review Paper
- 2023년 08월 (BRIC 등록일 2023-10-13)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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