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한빛사논문
- 조회277
Chem. Soc. Rev., Aug 23 2023 | https://doi.org/10.1039/d3cs00475a
Strategies to convert organic fluorophores into red/near-infrared emitting analogues and their utilization in bioimaging probes.
Mingchong Dai, *ab Yun Jae Yang,a Sourav Sarkara and Kyo Han Ahn *a
aDepartment of Chemistry, Pohang University of Science and Technology, Pohang, South Korea
bCEDAR, Knight Cancer Institute, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA
*Corresponding authors : Mingchong Dai, Kyo Han Ahn
Abstract
Organic fluorophores aided by current microscopy imaging modalities are essential for studying biological systems. Recently, red/near-infrared emitting fluorophores have attracted great research efforts, as they enable bioimaging applications with reduced autofluorescence interference and light scattering, two significant obstacles for deep-tissue imaging, as well as reduced photodamage and photobleaching. Herein, we analyzed the current strategies to convert key organic fluorophores bearing xanthene, coumarin, and naphthalene cores into longer wavelength-emitting derivatives by focussing on their effectiveness and limitations. Together, we introduced typical examples of how such fluorophores can be used to develop molecular probes for biological analytes, along with key sensing features. Finally, we listed several critical issues to be considered in developing new fluorophores.
논문정보
- Review Paper
- 2023년 08월 (BRIC 등록일 2023-10-13)
- 국내(교신)+국외 연구진
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