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Exp. Mol. Med., Sep 01 2023, | https://doi.org/10.1038/s12276-023-01071-4 Lipid remodeling of adipose tissue in metabolic health and disease.

Yoon Keun Cho^1,5, Sumin Lee^1,5, Jaewon Lee^1,5, Junsang Doh², Joo-Hong Park³, Young-Suk Jung⁴ and Yun-Hee Lee^1,*

¹College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.

²Department of Materials Science and Engineering, Research Institute of Advanced Materials, Institute of Engineering Research, Bio-MAX Institute, Soft Foundry Institute, Seoul National University, Seoul, Republic of Korea.

³School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.

⁴College of Pharmacy, Pusan National University, Busan, Republic of Korea.

⁵These authors contributed equally: Yoon Keun Cho, Sumin Lee, Jaewon Lee

^*Corresponding author : Correspondence to Yun-Hee Lee.

Abstract

Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipose tissue and its role in metabolic disorders such as obesity, diabetes, and cardiovascular disease. In addition, adipose tissue lipidomics has emerged as a powerful tool for understanding the molecular mechanisms underlying these disorders and identifying bioactive lipid mediators and potential therapeutic targets. This review aims to summarize recent lipidomics studies that investigated the dynamic remodeling of adipose tissue lipids in response to specific physiological changes, pharmacological interventions, and pathological conditions. We discuss the molecular mechanisms of lipid remodeling in adipose tissue and explore the recent identification of bioactive lipid mediators generated in adipose tissue that regulate adipocytes and systemic metabolism. We propose that manipulating lipid-mediator metabolism could serve as a therapeutic approach for preventing or treating obesity-related metabolic diseases.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-09-06)
연구진국내 연구진
분야 의약학 > 약학

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