한효빈 (한국과학기술연구원(KIST), 현 MIT) | 한빛사논문 > 한빛사

한빛사논문

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한효빈Hio-Been Han

한국과학기술연구원(KIST), 현 MIT

Proc. Natl. Acad. Sci. USA, Sep 12 2023, 120 (37) | https://doi.org/10.1073/pnas.2308762120 Dynamic switching of neural oscillations in the prefrontal-amygdala circuit for naturalistic freeze-or-flight.

Hio- Been Han^a,b, Hee- Sup Shin^c,d, Yong Jeong^b,e, Jisoo Kim^a,f, and Jee Hyun Choi^a,g,h,1

^aComputational Cognitive & Systems Neuroscience Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea;

^bProgram of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea;

^cCenter for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, Republic of Korea;

^dSL Bigen Co., Incheon 21983, Republic of Korea;

^eDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea;

^fDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, United Kingdom;

^gDivision of Bio- Medical Science & Technology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea; and

^hDepartment of Physics and Center for Theoretical Physics, Seoul National University, Seoul 08826, Republic of Korea

¹To whom correspondence may be addressed. : Jee Hyun Choi

Abstract

The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) are involved in the regulation of defensive behavior under threat, but their engagement in flexible behavior shifts remains unclear. Here, we report the oscillatory activities of mPFC-BLA circuit in reaction to a naturalistic threat, created by a predatory robot in mice. Specifically, we found dynamic frequency tuning among two different theta rhythms (~5 or ~10 Hz) was accompanied by agile changes of two different defensive behaviors (freeze-or-flight). By analyzing flight trajectories, we also found that high beta (~30 Hz) is engaged in the top-down process for goal-directed flights and accompanied by a reduction in fast gamma (60 to 120 Hz, peak near 70 Hz). The elevated beta nested the fast gamma activity by its phase more strongly. Our results suggest that the mPFC-BLA circuit has a potential role in oscillatory gear shifting allowing flexible information routing for behavior switches.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-09-07)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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