한빛사논문
- 조회336
POSTECH
Hyori Lee 1, Byullee Park 2,3, Jihye Lee 1, Yeoul Kang 1, Moongyu Han 2, Junseok Lee 1, Chulhong Kim 2, Won Jong Kim 1
1Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
2Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, Medical Science and Engineering, and School of, Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
3Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
H.L. and B.P. contributed equally to this work.
CORRESPONDING AUTHORS: Junseok Lee, Chulhong Kim, Won Jong Kim
Abstract
Transcytosis is an active transcellular transportation pathway that has garnered interest for overcoming the limited deep penetration of nanomedicines in solid tumors. In this study, a charge-convertible nanomedicine that facilitates deep penetration into solid tumors via transcytosis is designed. It is an albumin-based calcium phosphate nanomedicine loaded with IR820 (mAlb-820@CaP) for high-resolution photoacoustic imaging and enhanced photothermal therapy. Biomineralization on the surface stabilizes the albumin-IR820 complex during circulation and provides calcium ions (Ca2+ ) for tissue penetration on degradation in an acidic environment. pH-triggered transcytosis of the nanomedicine enabled by caveolae-mediated endocytosis and calcium ion-induced exocytosis in 2D cellular, 3D spheroid, and in vivo tumor models is demonstrated. Notably, the extravasation and penetration ability of the nanomedicine is observed in vivo using a high-resolution photoacoustic system, and nanomedicine shows the most potent photothermal antitumor effect in vivo. Overall, the strategy provides a versatile theragnosis platform for both noninvasive photoacoustic imaging and high therapeutic efficiency resulting from deep penetration of nanomedicine.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-09-13)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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