김종숙 (University of Illinois at Urbana-Champaign)

한빛사논문

조회306

University of Illinois at Urbana-Champaign

CV File 268 kb

Exp. Mol. Med., Sep 01 2023, | https://doi.org/10.1038/s12276-023-01072-3 MicroRNA regulation of AMPK in nonalcoholic fatty liver disease.

Hao Sun¹ and Jongsook Kim Kemper ^1,*

¹Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

^*Corresponding author: correspondence to Jongsook Kim Kemper

Abstract

Obesity-associated nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the leading cause of liver failure and death. The function of AMP-activated protein kinase (AMPK), a master energy sensor, is aberrantly reduced in NAFLD, but the underlying mechanisms are not fully understood. Increasing evidence indicates that aberrantly expressed microRNAs (miRs) are associated with impaired AMPK function in obesity and NAFLD. In this review, we discuss the emerging evidence that miRs have a role in reducing AMPK activity in NAFLD and nonalcoholic steatohepatitis (NASH), a severe form of NAFLD. We also discuss the underlying mechanisms of the aberrant expression of miRs that can negatively impact AMPK, as well as the therapeutic potential of targeting the miR-AMPK pathway for NAFLD/NASH.

논문정보

형식Review Paper
게재일2023년 09월 (BRIC 등록일 2023-10-10)
연구진국외 연구진
분야 생명과학 > 유전자발현

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