한빛사논문
- 조회519
Jaepil Jeong 1,2, Grzegorz Szczepaniak 1,3, Subha R. Das 1,2, Krzysztof Matyjaszewski 1,4
1Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA
2Center for Nucleic Acids Science & Technology, Carnegie Mellon University, Pittsburgh, PA, USA
3Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw, Poland
4Lead contact
Corresponding authors: Subha R. Das, Krzysztof Matyjaszewski
Abstract
Modifying biomacromolecules with synthetic polymers has been a powerful approach to developing multifunctional hybrid biomaterials for nanoscience and biomedical applications. With oligonucleotides, limited coupling and conjugation strategies were replaced with approaches allowing for the initiation of polymer chains directly from a terminus of synthetic DNA sequences. Although these strategies have provided access to diblock (DNA-polymer) bioconjugates, oligonucleotide biohybrids with more complex architectures have remained challenging. In this work, we vastly expand the possibility of creating diverse oligonucleotide-polymer biohybrids by developing serinol-based α-bromoisobutyryl (SBiB) phosphoramidite. This universal reagent allows for multiple site-specific incorporations of an atom-transfer radical polymerization (ATRP) initiator within a synthetic DNA or RNA sequence. Combining this methodology with the recently developed green-light-induced ATRP with dual catalysis has enabled the precise fabrication of well-defined, complex hybrid nucleic acid polymers.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-09-04)
- 국외 연구진
- 바이오·의료융합 > 바이오소재
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