한빛사논문, 상위피인용논문
- 조회485
Wonyoung Park1,2, Shibo Wei3, Bo-Sung Kim1,2, Bosung Kim1,2, Sung-Jin Bae4, Young Chan Chae5, Dongryeol Ryu6 and Ki-Tae Ha1,2,*
1Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea.
2Korean Medical Research Center for Healthy Aging, Pusan National University, Yangsan, Gyeongsangnam-do 50612, Republic of Korea.
3Department of Precision Medicine, School of Medicine, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do 16419, Republic of Korea.
4Department of Molecular Biology and Immunology, Kosin University College of Medicine, Busan 49267, Republic of Korea.
5Department of Biological Sciences, UNIST, Ulsan 44919, Republic of Korea.
6Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
*Corresponding author: correspondence to Ki-Tae Ha
Abstract
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimental evidence accumulated over the past few decades has revealed different types of cell death that are genetically programmed to eliminate unnecessary or severely damaged cells that may damage surrounding tissues. Several types of cell death, including apoptosis, necrosis, autophagic cell death, and lysosomal cell death, which are classified as programmed cell death, and pyroptosis, necroptosis, and NETosis, which are classified as inflammatory cell death, have been described over the years. Recently, several novel forms of cell death, namely, mitoptosis, paraptosis, immunogenic cell death, entosis, methuosis, parthanatos, ferroptosis, autosis, alkaliptosis, oxeiptosis, cuproptosis, and erebosis, have been discovered and advanced our understanding of cell death and its complexity. In this review, we provide a historical overview of the discovery and characterization of different forms of cell death and highlight their diversity and complexity. We also briefly discuss the regulatory mechanisms underlying each type of cell death and the implications of cell death in various physiological and pathological contexts. This review provides a comprehensive understanding of different mechanisms of cell death that can be leveraged to develop novel therapeutic strategies for various diseases.
논문정보
- Review Paper
- 2023년 08월 (BRIC 등록일 2023-09-07)
- 국내 연구진
- 생명과학 > 세포생물학
- 60회 이상 인용된 논문 (상위피인용논문 등록일 2024-08-05)
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