한빛사논문
- 조회431
Minjun Ahn1†, Won‑Woo Cho2†, Wonbin Park2, Jae‑Seong Lee3, Min‑Ju Choi3, Qiqi Gao4, Ge Gao4*, Dong‑Woo Cho2* and Byoung Soo Kim1,3*
1Medical Research Institute, Pusan National University, Yangsan 626841, Kyungnam, Korea
2Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea
3School of Biomedical Convergence Engineering, Pusan National University, Yangsan, Republic of Korea
4School of Medical Engineering, Beijing Institute of Technology, Beijing 100081, China
†Minjun Ahn and Won-Woo Cho contributed equally to this work.
*Correspondence: Ge Gao, Dong‑Woo Cho
Abstract
Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural and functional hallmarks of natural skin. Despite significant advances in in vitro skin modeling over the past few decades, different reproducible biofabrication strategies are required to reproduce the pathological features of diseased human skin compared to those used for healthy-skin models. To explain human skin modeling with pathological hallmarks, we first summarize the structural and functional characteristics of healthy human skin. We then provide an extensive overview of how to recreate diseased human skin models in vitro, including models for wounded, diabetic, skin-cancer, atopic, and other pathological skin types. We conclude with an outlook on diseased-skin modeling and its technical perspective for the further development of skin engineering.
논문정보
- Review Paper
- 2023년 08월 (BRIC 등록일 2023-09-18)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 의료기기
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