한빛사논문
- 조회522
Hyun Kim1,2, Xi Zhu1,3, Yiming Zhao4, Sophie A. Bell2,10, Philip R. Gehrman5,6, Daniel Cohen2, D. P. Devanand1,2,7, Terry E. Goldberg1,2,8, Seonjoo Lee1,2,4,9 and Alzheimer’s Disease Neuroimaging Initiative
1Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
2Area Brain Aging and Mental Health, New York State Psychiatric Institute, New York, NY, USA.
3Division of Anxiety, Mood, Eating, and Related Disorders, New York State Psychiatric Institute, New York, NY, USA.
4Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
5Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
6Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
7Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
8Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.
9Division of Mental Health Data Science, New York State Psychiatric Institute, New York, NY, USA.
10Present address: Department of Psychology, University of Virginia, Charlottesville, VA, USA.
*A complete listing of Alzheimer’s Disease Neuroimaging Initiative (ADNI) investigators can be found at: http://adni.loni.usc.edu/wp content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
Corresponding author : Correspondence to Hyun Kim.
Abstract
Sleep and related disorders could lead to changes in various brain networks, but little is known about the role of amyloid β (Aβ) burden-a key Alzheimer's disease (AD) biomarker-in the relationship between sleep disturbance and altered resting state functional connectivity (rsFC) in older adults. This cross-sectional study examined the association between sleep disturbance, Aβ burden, and rsFC using a large-scale dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Sample included 489 individuals (53.6% cognitively normal, 32.5% mild cognitive impairment, and 13.9% AD) who had completed sleep measures (Neuropsychiatric Inventory), PET Aβ data, and resting-state fMRI scans at baseline. Within and between rsFC of the Salience (SN), the Default Mode (DMN) and the Frontal Parietal network (FPN) were compared between participants with sleep disturbance versus without sleep disturbance. The interaction between Aβ positivity and sleep disturbance was evaluated using the linear regressions, controlling for age, diagnosis status, gender, sedatives and hypnotics use, and hypertension. Although no significant main effect of sleep disturbance was found on rsFC, a significant interaction term emerged between sleep disturbance and Aβ burden on rsFC of SN (β = 0.11, P = 0.006). Specifically, sleep disturbance was associated with SN hyperconnectivity, only with the presence of Aβ burden. Sleep disturbance may lead to altered connectivity in the SN when Aβ is accumulated in the brain. Individuals with AD pathology may be at increased risk for sleep-related aberrant rsFC; therefore, identifying and treating sleep problems in these individuals may help prevent further disease progression.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-08-24)
- 국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
