한빛사논문
- 조회713
Richard C. Law 1, Glenn Nurwono 2 & Junyoung O. Park 1
1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
2Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Corresponding author : Correspondence to Junyoung O. Park.
Abstract
Glycolysis is a universal metabolic process that breaks down glucose to produce adenosine triphosphate (ATP) and biomass precursors. The Entner-Doudoroff (ED) pathway is a glycolytic pathway that parallels textbook glycolysis but yields half as much ATP. Accordingly, in organisms that possess both glycolytic pathways (for example, Escherichia coli), its raison d'être remains a mystery. In this study, we found that the ED pathway provides a selective advantage during growth acceleration. Upon carbon and nitrogen upshifts, E. coli accelerates growth faster with than without the ED pathway. Concurrent isotope tracing reveals that the ED pathway flux increases faster than that of textbook glycolysis. We attribute the fast response time of the ED pathway to its strong thermodynamic driving force and streamlining of glucose import. Intermittent nutrient supply manifests the evolutionary advantage of the parallel glycolysis; thus, the dynamic nature of an ostensibly redundant pathway's role in promoting rapid adaptation constitutes a metabolic design principle.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-08-18)
- 국외 연구진
- 생명과학 > 생화학
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