한빛사논문
- 조회773
Min Young Chun,1,2,3 Hyemin Jang,1,4,5,6 Soo-Jong Kim,1,4,6,7 Yu Hyun Park,1,4,6,7 Jihwan Yun,1 Samuel N Lockhart,8 Michael Weiner,9 Charles De Carli,10 Seung Hwan Moon,11 Jae Yong Choi,12 Kyung Rok Nam,12 Byung-Hyun Byun,13 Sang-Moo Lim,13 Jun Pyo Kim,1,4,5,14 Yeong Sim Choe,1 Young Ju Kim,1,4 Duk L Na,1,4,5,15 Hee Jin Kim,1,4,5,6 Sang Won Seo1,4,5,6,16
1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea
2Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea
3Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, South Korea
4Neuroscience Center, Samsung Medical Center, Seoul, South Korea
5Samsung Alzheimer’s Convergence Research Center, Samsung Medical Center, Seoul, South Korea
6Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea
7Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, South Korea
8Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
9Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
10Department of Neurology, University of California-Davis, Davis, California, USA 11Departmentof Nuclear Medicine, Samsung Medical Center, Sungkyunkwan
University School of Medicine, Seoul, South Korea
12Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea
13Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea
14Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
15Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul, South Korea
16Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, South Korea
Correspondence to Dr Sang Won Seo and Dr Hyemin Jang.
HJ and SWS contributed equally.
Abstract
Objectives: Alzheimer's disease (AD) is characterised by amyloid-beta accumulation (A), tau aggregation (T) and neurodegeneration (N). Vascular (V) burden has been found concomitantly with AD pathology and has synergistic effects on cognitive decline with AD biomarkers. We determined whether cognitive trajectories of AT(N) categories differed according to vascular (V) burden.
Methods: We prospectively recruited 205 participants and classified them into groups based on the AT(N) system using neuroimaging markers. Abnormal V markers were identified based on the presence of severe white matter hyperintensities.
Results: In A+ category, compared with the frequency of Alzheimer's pathological change category (A+T-), the frequency of AD category (A+T+) was significantly lower in V+ group (31.8%) than in V- group (64.4%) (p=0.004). Each AT(N) biomarker was predictive of cognitive decline in the V+ group as well as in the V- group (p<0.001). Additionally, the V+ group showed more severe cognitive trajectories than the V- group in the non-Alzheimer's pathological changes (A-T+, A-N+; p=0.002) and Alzheimer's pathological changes (p<0.001) categories.
Conclusion: The distribution and longitudinal outcomes of AT(N) system differed according to vascular burdens, suggesting the importance of incorporating a V biomarker into the AT(N) system.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-08-18)
- 국내(교신)+국외 연구진
- 의약학 > 신경의학
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