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순천향대학교 부천병원

Psychiatry Res., Vol 327, Sep 2023, 115403 | https://doi.org/10.1016/j.psychres.2023.115403 Manganese level and cognitive decline in older adults with the APOE e4 allele: a preliminary study

Shin Gyeom Kim ^a, Young Min Choe ^b,c, Guk-Hee Suh ^b,c, Boung Chul Lee ^c,d, Ihn-Geun Choi ^c,e, Hyun Soo Kim ^f, Jaeuk Hwang ^g, Mu-Sung Keum ^h, Dahyun Yi ⁱ, Jee Wook Kim ^b,c

^aDepartment of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea
^bDepartment of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, 7 Keunjaebong-gil, Hwaseong, Gyeonggi 18450, Republic of Korea
^cDepartment of Psychiatry, Hallym University College of Medicine, Chuncheon, Gangwon 24252, Republic of Korea
^dDepartment of Neuropsychiatry, Hallym University Hangang Sacred Heart Hospital, Seoul 07247, Republic of Korea
^eDepartment of Psychiatry, Seoul W Psychiatric Office, Seoul 08503, Republic of Korea
^fDepartment of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, 7 Keunjaebong-gil, Hwaseong, Gyeonggi 18450, Republic of Korea
^gDepartment of Psychiatry, Soonchunhyang University hospital Seoul, Seoul 04401, Republic of Korea
^hDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul 03080, Republic of Korea
ⁱInstitute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul 03080, Republic of Korea

Corresponding author: Jee Wook Kim

Abstract

This study examined the relationship between serum manganese level and cognition, and the moderating effect of apolipoprotein E ε4 (APOE4) on this relationship. A total of 164 non-demented participants underwent clinical assessments including serum manganese level and cognition [episodic memory score (EMS), non-memory score (NMS) for executive function/attention/language/ visuospatial skill, and total score (TS)]. Serum manganese × APOE4 interaction had a significant effect on EMS and TS. Serum manganese level was inversely associated with EMS and TS in APOE4-positive but not APOE4-negative participants. APOE4 should be considered a key component in Alzheimer's disease studies that included manganese imbalance as a risk factor.

논문정보

형식Research article
게재일2023년 09월 (BRIC 등록일 2023-08-17)
연구진국내 연구진
분야 의약학 > 응용의학

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