한빛사논문
- 조회415
Choong-Gu Lee 1,2,3#, Kwang Hyun Cha 1,2,3#, Gi-Cheon Kim 4, Sin-Hyeog Im 5,6,7, Ho-Keun Kwon 4
1Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, Korea.
2Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Gangneung, Korea.
3Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26493, Korea.
4Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, and Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
5Department of Life Sciences, Pohang University of Science and Technology, Pohang, Korea.
6Institute for Convergence Research and Education, Yonsei University, Korea.
7ImmunoBiome Inc, Bio Open Innovation Center, Pohang, Korea.
Corresponding authors: Sin-Hyeog Im, Ho-Keun Kwon
#Contributed equally.
Abstract
Probiotics, live microorganisms that confer health benefits when consumed in adequate amounts, have gained significant attention for their potential therapeutic applications. The beneficial effects of probiotics are believed to stem from their ability to enhance intestinal barrier function, inhibit pathogens, increase beneficial gut microbes, and modulate immune responses. However, clinical studies investigating the effectiveness of probiotics have yielded conflicting results, potentially due to the wide variety of probiotic species and strains used, the challenges in controlling the desired number of live microorganisms, and the complex interactions between bioactive substances within probiotics. Bacterial cell wall components, known as effector molecules, play a crucial role in mediating the interaction between probiotics and host receptors, leading to the activation of signaling pathways that contribute to the health-promoting effects. Previous reviews have extensively covered different probiotic effector molecules, highlighting their impact on immune homeostasis. Understanding how each probiotic component modulates immune activity at the molecular level may enable the prediction of immunological outcomes in future clinical studies. In this review, we present a comprehensive overview of the structural and immunological features of probiotic effector molecules, focusing primarily on Lactobacillus and Bifidobacterium. We also discuss current gaps and limitations in the field and propose directions for future research to enhance our understanding of probiotic-mediated immunomodulation.
논문정보
- Review Paper
- 2023년 08월 (BRIC 등록일 2023-08-25)
- 국내 연구진
- 의약학 > 면역의학
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