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Int. J. Antimicrob. Agents, 2023 Aug 1;106941 | https://doi.org/10.1016/j.ijantimicag.2023.106941 Controlling biofilm and virulence properties of Gram-positive bacteria by targeting wall teichoic acid and lipoteichoic acid

Geum-Jae Jeong ^{a †}, Fazlurrahman Khan ^{b,c †}, Nazia Tabassum ^b,c, Kyung-Jin Cho ^a, Young-Mog Kim^a,b,c

^aDepartment of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea
^bMarine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan, 48513, Republic of Korea
^cResearch Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea

^†Equally contributed
Corresponding authors: Fazlurrahman Khan and Young-Mog Kim

Abstract

Wall teichoic acid (WTA) and lipoteichoic acid (LTA) are structural components of Gram-positive bacteria's peptidoglycan and cell membrane, which are mostly anionic glycopolymers. WTA confers numerous physiological, virulence, and pathogenic features to bacterial pathogens. It controls cell shape, cell division, and the localization of autolytic enzymes and ion homeostasis. In the context of virulence and pathogenicity, it aids bacterial cell attachment and colonization and protects against the host defense system and antibiotics. Having such a broad function in pathogenic bacteria's lifecycle, WTA/LTA become one of the potential targets for antibacterial agents to reduce bacterial infection in the host. The number of reports for targeting the WTA/LTA pathway has risen, mostly by focusing on three distinct targets: antivirulence targets, β-lactam potentiator targets, and essential targets. The current review looked at the role of WTA/LTA in biofilm development and virulence in a range of Gram-positive pathogenic bacteria. Furthermore, alternate strategies, such as the application of natural and synthetic compounds that target the WTA/LTA pathway, have been thoroughly discussed. Moreover, the application of nanomaterials and a combination of drugs have also been discussed as a viable method for targeting the WTA/LTA in numerous Gram-positive bacteria. In addition, a future perspective for controlling bacterial infection by targeting the WTA/LTA is proposed.

논문정보

형식Review Paper
게재일2023년 08월 (BRIC 등록일 2023-11-09)
연구진국내 연구진
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