한빛사논문
- 조회780
Kyungchul Noh1, Woo-Hyun Cho1, Byung Hun Lee2, Dong Wook Kim2, Yoo Sung Kim3, Keebum Park1, Minkyu Hwang1, Ellane Barcelon1, Yoon Kyung Cho4, C. Justin Lee5, Bo-Eun Yoon3, Se-Young Choi1, Hye Yoon Park2,6, Sang Beom Jun4,7,8 & Sung Joong Lee1,*
1Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
2Department of Physics and Astronomy, Seoul National University, Seoul, Republic of Korea.
3Department of Molecular Biology, Dankook University, Cheonan, Republic of Korea.
4Department of Electronic and Electrical Engineering, Ewha Womans University, Seoul, Republic of Korea.
5Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea.
6Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, USA.
7Graduate Program in Smart Factory, Ewha Womans University, Seoul, Republic of Korea.
8Department of Brain & Cognitive Sciences, Ewha Womans University, Seoul, Republic of Korea.
*Corresponding author: Sung Joong Lee
Abstract
Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between excitatory and inhibitory (E/I) neuronal activity, which may influence social behavior. However, the contribution of astrocytes in the prefrontal cortex to dominance behavior is unclear. Here we show that dorsomedial prefrontal cortical (dmPFC) astrocytes modulate E/I balance and dominance behavior in adult male mice using in vivo fiber photometry and two-photon microscopy. Optogenetic and chemogenetic activation or inhibition of dmPFC astrocytes show that astrocytes bidirectionally control male mouse dominance behavior, affecting social rank. Dominant and subordinate male mice present distinct prefrontal synaptic E/I balance, regulated by astrocyte activity. Mechanistically, we show that dmPFC astrocytes control cortical E/I balance by simultaneously enhancing presynaptic-excitatory and reducing postsynaptic-inhibitory transmission via astrocyte-derived glutamate and ATP release, respectively. Our findings show how dmPFC astrocyte–neuron communication can be involved in the establishment of social hierarchy in adult male mice.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-08-11)
- 국내(교신)+국외 연구진
- 생명과학 > 신경생물학
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