한빛사논문
- 조회514
Zhanping Ren 1, Anicca D Harriot 2, Devin B Mair 2, Michael K Chung 3, Peter H U Lee 4,5, Deok-Ho Kim 1,2,6,7,8
1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA.
3Spiritus Medical Inc, Columbus, OH, 43235, USA.
4Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
5Department of Cardiothoracic Surgery, Southcoast Health, Fall River, MA, 02720, USA.
6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
7Center for Microphysiological Systems, Johns Hopkins University, Baltimore, MD, 21205, USA.
8Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, 21218, USA.
CORRESPONDING AUTHORS : Peter H. U. Lee, Deok-Ho Kim
Abstract
The growing interest in bioengineering in-vivo-like 3D functional tissues has led to novel approaches to the biomanufacturing process as well as expanded applications for these unique tissue constructs. Microgravity, as seen in spaceflight, is a unique environment that may be beneficial to the tissue-engineering process but cannot be completely replicated on Earth. Additionally, the expense and practical challenges of conducting human and animal research in space make bioengineered microphysiological systems an attractive research model. In this review, published research that exploits real and simulated microgravity to improve the biomanufacturing of a wide range of tissue types as well as those studies that use microphysiological systems, such as organ/tissue chips and multicellular organoids, for modeling human diseases in space are summarized. This review discusses real and simulated microgravity platforms and applications in tissue-engineered microphysiological systems across three topics: 1) application of microgravity to improve the biomanufacturing of tissue constructs, 2) use of tissue constructs fabricated in microgravity as models for human diseases on Earth, and 3) investigating the effects of microgravity on human tissues using biofabricated in vitro models. These current achievements represent important progress in understanding the physiological effects of microgravity and exploiting their advantages for tissue biomanufacturing.
논문정보
- Review Paper
- 2023년 07월 (BRIC 등록일 2023-08-11)
- 국외 연구진
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