한빛사논문
- 조회395
Sung Eun Seo 1,†, Kyung Ho Kim 1,†, Siyoung Ha 1,†, Hanseul Oh 2, Jinyeong Kim 1, Soomin Kim 1, Lina Kim 1, Minah Seo 3,4, Jai Eun An 1, Yoo Min Park 5, Kyoung G Lee 5, Yu Kyung Kim 6, Woo-Keun Kim 7, Jung Joo Hong 8*, Hyun Seok Song 3*, Oh Seok Kwon 1, 9,10*
1Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea.
2College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Republic of Korea.
3Sensor System Research Center, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
4KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
5Center for NanoBio Development, National NanoFab Center, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
6Department of Clinical Pathology, School of Medicine, Kyungpook National University, Republic of Korea.
7Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, South Korea.
8National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea.
9SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
10Department of Nano Science and Technology, Sungkyunkwan University, Suwon, 16419, South Korea.
†Contributed equally
*Corresponding authors: Jung Joo Hong, Hyun Seok Song, Oh Seok Kwon
Abstract
The transmission and pathogenesis of highly contagious fatal respiratory viruses are increasing, and the need for an on-site diagnostic platform has arisen as an issue worldwide. Furthermore, as the spread of respiratory virus continues, different variants have become the dominant circulating strains. To prevent virus transmission, the development of highly sensitive and accurate on-site diagnostic assays is urgently needed. Herein, we present a facile diagnostic device for multi-detection based on the results of detailed receptor-ligand dynamics simulations for the screening of various viral strains. Our novel bioreceptor-treated electronics (receptonics) device consists of a multichannel graphene transistor and cell-entry receptors conjugated to N-heterocyclic carbene (NHC). We achieved ultrasensitive multi-detection performance without the need for sample pretreatment, which will enable rapid diagnosis and prevent the spread of pathogens. This platform can be applied for the diagnosis of variants of concern in clinical respiratory virus samples and primate models. Our multi-screening platform can be used to enhance surveillance and discriminate emerging virus variants before they become a severe threat to public health.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-09-18)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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