한빛사논문
- 조회597
HyeMi Kim 1, Yujin Baek 2, Taeyong Ha 3, Doowon Choi 4, Woo Jin Lee 3, Yongbum Cho 4, Jeehun Park 5, Sungjee Kim 3,4, Junsang Doh 2,5,6
1Center for Scientific Instrumentation, Korea Basic Science Institute (KBSI), Daejeon, 34133, South Korea.
2Department of Materials Science and Engineering, Seoul National University, Seoul, 08826, South Korea.
3Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
4School of Interdisciplinary Bioscience and Bioengineering (I-Bio), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
5SOFT Foundry Institute, Seoul National University, Seoul, 08826, South Korea.
6Research Institute of Advanced Materials (RIAM), Institute of Engineering Research, BioMAX Institute, Seoul National University, Seoul, 08826, South Korea.
H.K. and Y.B. contributed equally to this work.
CORRESPONDING AUTHORS : Sungjee Kim, Junsang Doh
Abstract
Cancer immunotherapy is a promising therapy to treat cancer patients with minimal toxicity, but only a small fraction of patients responded to it as a monotherapy. In this study, a strategy to boost therapeutic efficacy by combining an immunotherapy based on ex vivo expanded tumor-reactive T cells is devised, or adoptive cell therapy (ACT), with photothermal therapy (PTT). Smart gold nanoparticles (sAuNPs), which aggregates to form gold nanoclusters in the cells, are loaded into T cells, and their photothermal effects within T cells are confirmed. When transferred into tumor-bearing mice, large number of sAuNP-carrying T cells successfully infiltrate into tumor tissues and exert anti-tumor activity to suspend tumor growth, but over time tumor cells evade and regrow. Of note, ≈20% of injected doses of sAuNPs are deposited in tumor tissues, suggesting T cells are an efficient nanoparticle tumor delivery vehicle. When T cells no longer control tumor growth, PTT is performed to further eliminate tumors. In this manner, ACT and PTT are temporally coupled, and the combined immuno-photothermal treatment demonstrated significantly greater therapeutic efficacy than the monotherapy.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-08-08)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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