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Chem. Soc. Rev., 2023 Jul 24 | https://doi.org/10.1039/D2CS00799A Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Shuang Zeng,^†ab, Xiaosheng Liu^,†b, Yves S. Kafuti,^†b, Heejeong Kim,^c, Jingyun Wang,^*ab, Xiaojun Peng,^*a, Haidong Li^*abd and Juyoung Yoon^*c

^aState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China
^bSchool of Bioengineering, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian 116024, China
^cDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
^dProvincial Key Laboratory of Interdisciplinary Medical Engineering for Gastrointestinal Carcinoma, Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital & Institute), Shenyang, Liaoning 110042, China

^†These authors contributed equally to this work.
^*Corresponding authors : Jingyun Wang, Xiaojun Peng, Haidong Li, Juyoung Yoon

Abstract

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to their good optical physical properties. Accordingly, they have emerged as a powerful tool for the visualization of living systems. In addition to fluorescence bioimaging, the molecular design of rhodamine derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important for the construction of molecular libraries for diagnostic and therapeutic integration. However, reviews focusing on integrated design strategies for rhodamine dye-based diagnosis and treatment and their wide application in disease treatment are extremely rare. In this review, first, a brief history of the development of rhodamine fluorescent dyes, the transformation of rhodamine fluorescent dyes from bioimaging to disease therapy, and the concept of optics-based diagnosis and treatment integration and its significance to human development are presented. Next, a systematic review of several excellent rhodamine-based derivatives for bioimaging, as well as for disease diagnosis and treatment, is presented. Finally, the challenges in practical integration of rhodamine-based diagnostic and treatment dyes and the future outlook of clinical translation are also discussed.

논문정보

형식Review Paper
게재일2023년 07월 (BRIC 등록일 2023-08-17)
연구진국내(교신)+국외 연구진
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