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Biosens. Bioelectron., Available online 4 Aug 2023, 115571 | https://doi.org/10.1016/j.bios.2023.115571 Microneedles coated with composites of phenylboronic acid-containing polymer and carbon nanotubes for glucose measurements in interstitial fluids

Jae Hoon Han ^a,1, Cho Rim Kim ^a,1, Chang Hee Min ^a, Min Ji Kim ^a, Se-Na Kim ^b, Han Bi Ji ^b, Soo Bin Yoon ^a, Cheol Lee ^c, Young Bin Choy ^a,b,d,e,f

^aInterdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea
^bInstitute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea
^cDepartment of Pathology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea
^dDepartment of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea
^eInnovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, 03122, Republic of Korea
^fToBIOs Inc, 214 Yulgok-ro, Jongno-gu, Seoul, 03122, Republic of Korea

¹These authors contributed equally to this work.
Corresponding author : Young Bin Choy

Abstract

A microneedle (MN) sensor coated with a sensing composite material was proposed for measuring glucose concentrations in interstitial fluid (ISF). The sensing composite material was prepared by blending a polymer containing glucose-responsive phenylboronic acid (PBA) moieties (i.e., polystyrene-block-poly(acrylic acid-co-acrylamidophenylboronic acid)) with conductive carbon nanotubes (CNTs). The polymer exhibited reversible swelling behavior in response to glucose concentrations, which influenced the distribution of the embedded CNTs, resulting in sensitive variations in electrical percolation, even when coated onto a confined surface of the MN in the sensor. We varied the ratio of PBA moieties and the loading amount of CNTs in the sensing composite material of the MN sensor and tested them in vitro using an ISF-mimicking gel with physiological glucose concentrations to determine the optimal sensitivity conditions. When tested in animal models with varying blood glucose concentrations, the MN sensor coated with the selected sensing material exhibited a strong correlation between the measured electrical currents and blood glucose concentrations, showing accuracy comparable to that of a glucometer in clinical use.

논문정보

형식Research article
게재일2023년 08월 (BRIC 등록일 2023-08-07)
연구진국내 연구진
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