한빛사논문
- 조회296
Prerak Gupta a,b, Omar Alheib c,d, Jae-Won Shin a,b
aDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
bDepartment of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA
c3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal
dICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, 4805-017, Portugal
Corresponding author : Jae-Won Shin
Abstract
The primary impetus of therapeutic cell encapsulation in the past several decades has been to broaden the options for donor cell sources by countering against rejection by the host immune system. The general paradigm of the field has been to develop encapsulating materials that promote immune evasion, thereby enabling donor cells to reside in the host and to secrete therapeutic molecules. However, another significant advantage of encapsulation is to provide donor cells with instructive cues that could be compromised in the host with disease conditions. The advances in biomaterial design have led to fundamental insights that cells sense and respond to various signals encoded in materials, ranging from biochemical to mechanical cues. The biomaterial design for cell encapsulation is becoming more sophisticated in controlling specific aspects of cellular phenotypes and more precise down to the single cell level. This recent progress offers a paradigm shift by designing single cell-encapsulating materials with predefined cues to predictably control donor cells after transplantation.
논문정보
- Review Paper
- 2023년 07월 (BRIC 등록일 2023-08-22)
- 국외 연구진
- 바이오·의료융합 > 바이오소재
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