한빛사논문
- 조회370
Nam Hyeong Kim 1,2, Sudong Chae 3, Sang Ah Yi 4,5, Deok Hyang Sa 1,2, Seungbae Oh 3, Eun Sung Kang 1,2, Suhyeon Kim 1,2, Kyung Hwan Choi 1,2,6, Jaecheol Lee 4,7,8,9, Jae-Young Choi 1,2,3, Yong Ho Kim 1,2,7,8,10,11,12
1SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon 16419, Republic of Korea.
2Department of Nano Science and Technology, Sungkyunkwan University, Suwon 16419, Republic of Korea.
3School of Advanced Materials Science & Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
4School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
5Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
6Department of Biohealth Regulatory Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
7Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Republic of Korea.
8Imnewrun Inc., Suwon 16419, Republic of Korea.
9Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
10Department of Nano Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
11Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 16419, Republic of Korea.
12Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
N.H.C., S.C., and S.A.Y. contributed equally.
Corresponding Authors : Jaecheol Lee, Jae-Young Choi, Yong Ho Kim
Abstract
Nanomaterials hybridized with biological components have widespread applications. among many candidates, peptides are attractive in that their peptide sequences can self-assemble with the surface of target materials with high specificity without perturbing the intrinsic properties of nanomaterials. Here, a 1D hybrid nanomaterial was developed through self-assembly of a designed peptide. A hexagonal coiled-coil motif geometrically matched to the diameter of the inorganic nanomaterial was fabricated, whose hydrophobic surface was wrapped along the axis of the hydrophobic core of the coiled coil. Our morphological and spectroscopic analyses revealed rod-shaped, homogeneous peptide–inorganic nanomaterial complexes. Culturing embryonic stem cells on surfaces coated with this peptide-assembled single-chain atomic crystal increased the growth and adhesion of the embryonic stem cells. The hybridized nanomaterial also served as an ECM for brain organoids, accelerating the maturation of neurons. New methods to fabricate hybrid materials through peptide assembly can be applied.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-08-22)
- 국내(교신)+국외 연구진
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