한빛사논문
- 조회637
Sujin Noh 1, Yong Jun Jin 2, Dong Il Shin 3, Hyeon Jae Kwon 3, Hee-Woong Yun 2,4, Kyu Min Kim 4, Jae-Young Park 5, Jun Young Chung 2, Do Young Park 1,2,4,6
1Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.
2Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon, Republic of Korea.
3Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.
4Cell Therapy Center, Ajou Medical Center, Suwon, Republic of Korea.
5Department of Orthopedics Surgery, CHA University Bundang Medical Center, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.
6Ajou university, Leading Convergence of Healthcare and Medicine, Institute of Science & Technology (ALCHeMIST).
CORRESPONDING AUTHOR : Do Young Park
Abstract
Degenerative meniscus tears (DMTs) are prevalent findings in osteoarthritic knees, yet current treatment is mostly limited to arthroscopic partial meniscectomy rather than regeneration, which further exacerbates arthritic changes. Translational research regarding meniscus regeneration is hindered by the complex, composite nature of the meniscus which exhibit a gradient from inner cartilage-like tissue to outer fibrous tissue, as well as engineering hurdles often requiring growth factors and cross-linking agents. We aimed to replicate the meniscus zonal tissue gradient using zone-specific decellularized meniscus extracellular matrix (DMECM) and autologous synovial mesenchymal stem cells (MSCs) via self-aggregation without the use of growth factors or cross-linking agents. Combination with zone-specific DMECM during self-aggregation of MSCs formed zone-specific meniscus tissue that reflected the respective DMECM harvest site. The implantation of these constructs led to the regeneration of meniscus tissue resembling the native meniscus, demonstrating inner cartilaginous and outer fibrous characteristics as well as recovery of native meniscal microarchitecture in a porcine partial meniscectomy model at 6 months. In all, our findings offer a potential regenerative therapy for DMTs that may improve current partial meniscectomy-based patient care.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2023-08-08)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
