한빛사논문
- 조회655
Hanae Lim 1, Chaeun Oh 2, Myong-Suk Park 3, Hyung-Bin Park 1,4, Chaewon Ahn 1,4, Woo Kyun Bae 3, Kyung Hyun Yoo 2,5, Seungwoo Hong 4
1Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea.
2Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Korea.
3Division of Hemato-Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Korea.
4Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Korea.
5Research Institute of Women's Health, Sookmyung Women's University, Seoul 04310, Korea.
H.L. and C.O. contributed equally to this work.
Corresponding Authors : Woo Kyun Bae, Kyung Hyun Yoo, Seungwoo Hong
Abstract
Superoxide dismutases (SODs) are essential antioxidant enzymes that prevent massive superoxide radical production and thus protect cells from damage induced by free radicals. However, this concept has rarely been applied to directly impede the function of driver oncogenes, thus far. Here, leveraging efforts from SOD model complexes, we report the novel finding of biomimetic copper complexes that efficiently scavenge intracellularly generated free radicals and, thereby, directly access the core consequence of colorectal cancer suppression. We conceived four structurally different SOD-mimicking copper complexes that showed distinct disproportionation reaction rates of intracellular superoxide radical anions. By replenishing SOD models, we observed a dramatic reduction of intracellular reactive oxygen species (ROS) and adenine 5'-triphosphate (ATP) concentrations that led to cell cycle arrest at the G2/M stage and induced apoptosis in vitro and in vivo. Our results showcase how nature-mimicking models can be designed and fine-tuned to serve as a viable chemotherapeutic strategy for cancer treatment.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-08-18)
- 국내 연구진
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