한빛사논문
- 조회313
Yeongho Kim and Christopher G. Burd
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Correspondence: Christopher G. Burd
Abstract
The sorting and trafficking of lipids between organelles gives rise to a dichotomy of bulk membrane properties between organelles of the secretory and endolysosome networks, giving rise to two “membrane territories” based on differences in lipid-packing density, net membrane charge, and bilayer leaflet asymmetries. The cellular organelle membrane dichotomy emerges from ER-to-PM anterograde membrane trafficking and the synthesis of sphingolipids and cholesterol flux at the trans-Golgi network, which constitutes the interface between the two membrane territories. Organelle homeostasis is maintained by vesicle-mediated retrieval of bulk membrane from the distal organelles of each territory to the endoplasmic reticulum or plasma membrane and by soluble lipid transfer proteins that traffic particular lipids. The concept of cellular membrane territories emphasizes the contrasting features of organelle membranes of the secretory and endolysosome networks and the essential roles of lipid-sorting pathways that maintain organelle function.
논문정보
- Review Paper
- 2023년 07월 (BRIC 등록일 2023-08-01)
- 국외 연구진
- 생명과학 > 세포생물학
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