한빛사논문
- 조회780
Saebyeol Lee 1, Jungeun Kim 1, Paul N. Valdmanis 2 and Hak Kyun Kim 1,*
1Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea.
2Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98115, USA.
*Corresponding author: correspondence to Hak Kyun Kim
Abstract
Transfer RNAs (tRNAs) play an essential role in mRNA translation by delivering amino acids to growing polypeptide chains. Recent data demonstrate that tRNAs can be cleaved by ribonucleases, and the resultant cleavage products, tRNA-derived small RNAs (tsRNAs), have crucial roles in physiological and pathological conditions. They are classified into more than six types according to their size and cleavage positions. Since the initial discovery of the physiological functions of tsRNAs more than a decade ago, accumulating data have demonstrated that tsRNAs play critical roles in gene regulation and tumorigenesis. These tRNA-derived molecules have various regulatory functions at the transcriptional, post-transcriptional, and translational levels. More than a hundred types of modifications are found on tRNAs, affecting the biogenesis, stability, function, and biochemical properties of tsRNA. Both oncogenic and tumor suppressor functions have been reported for tsRNAs, which play important roles in the development and progression of various cancers. Abnormal expression patterns and modification of tsRNAs are associated with various diseases, including cancer and neurological disorders. In this review, we will describe the biogenesis, versatile gene regulation mechanisms, and modification-mediated regulation mechanisms of tsRNA as well as the expression patterns and potential therapeutic roles of tsRNAs in various cancers.
논문정보
- Review Paper
- 2023년 07월 (BRIC 등록일 2023-07-25)
- 국내(교신)+국외 연구진
- 생명과학 > 유전자발현
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