한빛사논문
- 조회314
Johns Hopkins University School /Max Planck Florida Institute for Neuroscience
Kanghoon Jung 1,2,5, Minhyeok Chang 1,6, André Steinecke 2,6, Benjamin Burke 1, Youngjin Choi 1, Yasuhiro Oisi 2, David Fitzpatrick 2, Hiroki Taniguchi 2,3 & Hyung-Bae Kwon 1,2,4,*
1Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
2Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
3Department of Pathology, Chronic Brain Injury program, Ohio State University, Columbus, OH, USA.
4Max Planck Institute of Neurobiology, Martinsried, Germany.
5Present address: Allen Institute for Neural Dynamics, Seattle, WA, USA.
6These authors contributed equally: Minhyeok Chang, André Steinecke.
*Corresponding author: correspondence to Hyung-Bae Kwon
Abstract
Genetically defined subgroups of inhibitory interneurons are thought to play distinct roles in learning, but heterogeneity within these subgroups has limited our understanding of the scope and nature of their specific contributions. Here we reveal that the chandelier cell (ChC), an interneuron type that specializes in inhibiting the axon-initial segment (AIS) of pyramidal neurons, establishes cortical microcircuits for organizing neural coding through selective axo-axonic synaptic plasticity. We found that organized motor control is mediated by enhanced population coding of direction-tuned premotor neurons, with tuning refined through suppression of irrelevant neuronal activity. ChCs contribute to learning-dependent refinements by providing selective inhibitory control over individual pyramidal neurons rather than global suppression. Quantitative analysis of structural plasticity across axo-axonic synapses revealed that ChCs redistributed inhibitory weights to individual pyramidal neurons during learning. These results demonstrate an adaptive logic of the inhibitory circuit motif responsible for organizing distributed neural representations. Thus, ChCs permit efficient cortical computation in a targeted cell-specific manner.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-08-22)
- 국외 연구진
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