한빛사논문
- 조회255
Sangbae Park1,2,3,4†, Yonghyun Gwon1,2,3†, Shahidul Ahmed Khan1,2,3, Kyoung‑Je Jang5,6* and Jangho Kim1,2,3,4*
1Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea
2Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea
3Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju 61186, Republic of Korea
4Institute of Nano‑Stem Cells Therapeutics, NANOBIOSYSTEM Co, Ltd, Gwangju 61011, Republic of Korea
5Department of Bio‑Systems Engineering, Institute of Smart Farm, Gyeongsang National University, Jinju 52828, Republic of Korea
6Institute of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea
†Sangbae Park and Yonghyun Gwon contributed equally to this work.
*Correspondence: Kyoung‑Je Jang, Jangho Kim
Abstract
Personalized medicine aims to provide tailored medical treatment that considers the clinical, genetic, and environmental characteristics of patients. iPSCs have attracted considerable attention in the field of personalized medicine; however, the inherent limitations of iPSCs prevent their widespread use in clinical applications. That is, it would be important to develop notable engineering strategies to overcome the current limitations of iPSCs. Such engineering approaches could lead to significant advances in iPSC-based personalized therapy by offering innovative solutions to existing challenges, from iPSC preparation to clinical applications. In this review, we summarize how engineering strategies have been used to advance iPSC-based personalized medicine by categorizing the development process into three distinctive steps: 1) the production of therapeutic iPSCs; 2) engineering of therapeutic iPSCs; and 3) clinical applications of engineered iPSCs. Specifically, we focus on engineering strategies and their implications for each step in the development of iPSC-based personalized medicine.
논문정보
- Review Paper
- 2023년 07월 (BRIC 등록일 2023-07-19)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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