한빛사논문
- 조회274
Matthew C. Woodruff 1,2,12,13, Kevin S. Bonham 3,12, Fabliha A. Anam 1,2, Tiffany A. Walker 4, Caterina E. Faliti 1,2, Yusho Ishii 1,2, Candice Y. Kaminski 5, Martin C. Ruunstrom 6, Kelly Rose Cooper 1,2, Alexander D. Truong 6, Adviteeya N. Dixit 6, Jenny E. Han 6, Richard P. Ramonell 7, Natalie S. Haddad 8, Mark E. Rudolph 9, Srilakshmi Yalavarthi 10, Viktoria Betin 11, Ted Natoli 11, Sherwin Navaz 10, Scott A. Jenks 1,2, Yu Zuo 10, Jason S. Knight 10, Arezou Khosroshahi 1,2, F. Eun-Hyung Lee 6,13 & Ignacio Sanz 1,2,13
1Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
2Emory Autoimmunity Center of Excellence, Emory University, Atlanta, GA, USA.
3Department of Biological Sciences, Wellesley College, Wellesley, MA, USA.
4Department of Medicine, Division of General Internal Medicine, Emory University, Atlanta, GA, USA.
5School of Medicine, Emory University, Atlanta, GA, USA.
6Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA, USA.
7Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
8MicroB-plex, Atlanta, GA, USA.
9Exagen Inc., Vista, CA, USA.
10Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.
11ImmuneID Inc., Waltham, MA, USA.
12These authors contributed equally: Matthew C. Woodruff, Kevin S. Bonham.
13These authors jointly supervised this work: Matthew C. Woodruff, F. Eun-Hyung Lee, Ignacio Sanz.
Corresponding authors : Correspondence to Matthew C. Woodruff, F. Eun-Hyung Lee or Ignacio Sanz.
Abstract
While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations, understanding if specific disease features associate with discrete immune processes and therapeutic opportunities is important. Here we profile patients in the recovery phase of COVID-19 via proteomics screening and machine learning to find signatures of ongoing antiviral B cell development, immune-mediated fibrosis, and markers of cell death in PASC patients but not in controls with uncomplicated recovery. Plasma and immune cell profiling further allow the stratification of PASC into inflammatory and non-inflammatory types. Inflammatory PASC, identifiable through a refined set of 12 blood markers, displays evidence of ongoing neutrophil activity, B cell memory alterations, and building autoreactivity more than a year post COVID-19. Our work thus helps refine PASC categorization to aid in both therapeutic targeting and epidemiological investigation of PASC.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-08-22)
- 국외 연구진
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