한빛사논문
- 조회393
Hyoung Woo Kim 1, Shuaiwei Wang 2, Alexander J. Davies 2, Seog Bae Oh 1
1Department of Neurobiology and Physiology, School of Dentistry, and Dental Research Institute, Seoul National University, Seoul, Republic of Korea
2Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
Correspondence: Alexander J. Davies, Seog Bae Oh
Abstract
Novel disease-modifying treatments for neuropathic pain are urgently required. The cellular immune response to nerve injury represents a promising target for therapeutic development. Recently, the role of natural killer (NK) cells in both CNS and PNS disease has been the subject of growing interest. In this opinion article, we set out the case for NK cell-based intervention as a promising avenue for development in the management of neuropathic pain. We explore the potential cellular and molecular targets of NK cells in the PNS by contrasting with their reported functional roles in CNS diseases, and we suggest strategies for using the beneficial functions of NK cells and immune-based therapeutics in the context of neuropathic pain.
논문정보
- Review Paper
- 2023년 06월 (BRIC 등록일 2023-07-14)
- 국내(교신)+국외 연구진
- 의약학 > 신경의학
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