한빛사논문
- 조회514
Matthew Baker 1,7, Seungwoo Kang 1,2,7, Sa-Ik Hong 1, Minryung Song 3, Minsu Abel Yang 3, Lee Peyton 1, Hesham Essa 1, Sang Wan Lee 3,4 & Doo-Sup Choi 1,5,6,*
1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
2Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
3Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
4Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
5Department of Psychiatry and Psychology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
6Neuroscience Program, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
7These authors contributed equally: Matthew Baker, Seungwoo Kang.
*Corresponding author: correspondence to Doo-Sup Choi
Abstract
The external globus pallidus (GPe) coordinates action-selection through GABAergic projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively to the dorsal striatum, which regulates goal-directed and habitual seeking. However, the role of GPe arky neurons in reward-seeking remains unknown. Here, we identified that a majority of arky neurons target the dorsolateral striatum (DLS). Using fiber photometry, we found that arky activities were higher during random interval (RI; habit) compared to random ratio (RR; goal) operant conditioning. Support vector machine analysis demonstrated that arky neuron activities have sufficient information to distinguish between RR and RI behavior. Genetic ablation of this arkyGPe→DLS circuit facilitated a shift from goal-directed to habitual behavior. Conversely, chemogenetic activation globally reduced seeking behaviors, which was blocked by systemic D1R agonism. Our findings reveal a role of this arkyGPe→DLS circuit in constraining habitual seeking in male mice, which is relevant to addictive behaviors and other compulsive disorders.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-07-14)
- 국내+국외 연구진
- 의약학 > 신경의학
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