한빛사논문
Jinwoo Hong 1, Taeyeon Kim 1, Jehan Kim 2, Yongju Kim 1,3
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
2Pohang Accelerator Laboratory, POSTECH, Pohang, 37673 Gyeongbuk, Republic of Korea.
3Department of Integrative Energy Engineering, Korea University, Seoul 02841, Republic of Korea.
J.H. and T.K. contributed equally.
Corresponding Author : Yongju Kim
Abstract
Variations in the functionalities of materials of different dimensions containing the same functional groups can be attributed to the structural stability and morphology of the materials. The morphology of peptide assemblies can influence their interactions with biological systems and ultimately modulate their bioactivity. Among reported Arg-Gly-Asp (RGD)-based supramolecular materials, two-dimensional (2-D) peptide assembly has been rarely studied. Herein, we report the fabrication of RGD-based supramolecular one-dimensional (1-D) and 2-D assemblies as peptide-based myoblast growth accelerators. The 2-D assembly was more effective in proliferating C2C12 cells than the 1-D assembly. These findings provide insights into the construction of optimal RGD-based supramolecular functional materials of different dimensions.
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