한빛사논문
- 조회418
Mingyu Lee 1, Junggeon Park 1, Goeun Choe 1, Sanghun Lee 1, Bo Gyeong Kang 2, Ju Hee Jun 2, Yoonmin Shin 3, Min Chul Kim 3,4, Yong Sook Kim 2,5, Youngkeun Ahn 2,3,4, Jae Young Lee 1
1School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
2Cell Regeneration Research Center, Chonnam National University, Gwangju 61005, Republic of Korea.
3Department of Cardiology, Chonnam National University Hospital, Gwangju 61005, Republic of Korea.
4Chonnam National University Medical School, Gwangju 61005, Republic of Korea.
5Biomedical Research Institute, Chonnam National University Hospital, Gwangju 61005, Republic of Korea.
Corresponding Authors : Yong Sook Kim, Youngkeun Ahn, Jae Young Lee
Abstract
Myocardial infarction (MI) is a major cause of death worldwide. After the occurrence of MI, the heart frequently undergoes serious pathological remodeling, leading to excessive dilation, electrical disconnection between cardiac cells, and fatal functional damage. Hence, extensive efforts have been made to suppress pathological remodeling and promote the repair of the infarcted heart. In this study, we developed a hydrogel cardiac patch that can provide mechanical support, electrical conduction, and tissue adhesiveness to aid in the recovery of an infarcted heart function. Specifically, we developed a conductive and adhesive hydrogel (CAH) by combining the two-dimensional titanium carbide (Ti3C2Tx) MXene with natural biocompatible polymers [i.e., gelatin and dextran aldehyde (dex-ald)]. The CAH was formed within 250 s of mixing the precursor solution and could be painted. The hydrogel containing 3.0 mg/mL MXene, 10% gelatin, and 5% dex-ald exhibited appropriate material characteristics for cardiac patch applications, including a uniform distribution of MXene, a high electrical conductivity (18.3 mS/cm), cardiac tissue-like elasticity (30.4 kPa), strong tissue adhesion (6.8 kPa), and resistance to various mechanical deformations. The CAH was cytocompatible and induced cardiomyocyte (CM) maturation in vitro, as indicated by the upregulation of connexin 43 expression and a faster beating rate. Furthermore, CAH could be painted onto the heart tissue and remained stably adhered to the beating epicardium. In vivo animal studies revealed that CAH cardiac patch treatment significantly improved cardiac function and alleviated the pathological remodeling of an infarcted heart. Thus, we believe that our MXene-based CAH can potentially serve as a promising platform for the effective repair of various electroactive tissues including the heart, muscle, and nerve tissues.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-07-12)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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