한빛사논문
- 조회553
BumJin Ko 1, Jong-Yeon Yoo 1, Taesik Yoo 1, Woochul Choi 2, Rumeysa Dogan 1, Kibong Sung 1, Dahun Um 1, Su Been Lee 1, Hyun Jin Kim 1, Sangjun Lee 1, Seung Tae Beak 1,3, Sang Ki Park 1,3, Se-Bum Paik 2, Tae-Kyung Kim 1,3, Joung-Hun Kim 1,3,4
1Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Nam-gu, Pohang, Gyeongbuk 37673, Republic of Korea
2Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
3Institute of Convergence Science, Yonsei University, Seoul 03722, Republic of Korea
4Lead contact
Corresponding author : Joung-Hun Kim
Abstract
Amygdala circuitry encodes associations between conditioned stimuli and aversive unconditioned stimuli and also controls fear expression. However, whether and how non-threatening information for unpaired conditioned stimuli (CS-) is discretely processed remains unknown. The fear expression toward CS- is robust immediately after fear conditioning but then becomes negligible after memory consolidation. The synaptic plasticity of the neural pathway from the lateral to the anterior basal amygdala gates the fear expression of CS-, depending upon neuronal PAS domain protein 4 (Npas4)-mediated dopamine receptor D4 (Drd4) synthesis, which is precluded by stress exposure or corticosterone injection. Herein, we show cellular and molecular mechanisms that regulate the non-threatening (safety) memory consolidation, supporting the fear discrimination.
논문정보
- Research article
- 2023년 06월 (BRIC 등록일 2023-07-12)
- 국내 연구진
- 생명과학 > 신경생물학
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