한빛사논문
Young-Gun Lee 1,2, Seun Jeon 1,3,4, Sung Woo Kang 1, Byoung Seok Ye 1,4
1Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
2Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, South Korea.
3Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
4Metabolism-Dementia Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
Young-gun Lee and Seun Jeon contributed equally to this work.
CORRESPONDING AUTHOR : Byoung Seok Ye
Abstract
Introduction: Although mixed pathologies are common in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), the effects of amyloid beta and dopaminergic depletion on brain perfusion and clinical symptoms have not been elucidated.
Methods: In 99 cognitive impairment patients due to AD and/or DLB and 32 controls, 18F-florbetaben (FBB) and dual-phase dopamine transporter (DAT) positron emission tomography (PET) were performed to measure the FBB standardized uptake value ratio (SUVR), striatal DAT uptakes, and brain perfusion.
Results: Higher FBB-SUVR and lower ventral striatal DAT uptake were intercorrelated and, respectively, associated with left entorhinal/temporo-parietal-centered hypoperfusion and vermis/hippocampal-centered hyperperfusion, whereas regional perfusion mediated clinical symptoms and cognition.
Discussion: Amyloid beta deposition and striatal dopaminergic depletion contribute to regional perfusion changes, clinical symptoms, and cognition in the spectrum of normal aging and cognitive impairment due to AD and/or LBD.
Highlights: Amyloid beta (Aβ) deposition was associated with ventral striatal dopaminergic depletion. Aβ deposition and dopaminergic depletion correlated with perfusion. Aβ deposition correlated with hypoperfusion centered in the left entorhinal cortex. Dopaminergic depletion correlated with hyperperfusion centered in the vermis. Perfusion mediated the Aβ deposition/dopaminergic depletion's effects on cognition.
논문정보
관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기