한빛사논문
- 조회536
JeongJun Park 1,2†, Seolmin Kim 1,3†, HyungGoo R. Kim 1,3, Joonyeol Lee 1,3,4*
1Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 16419, Republic of Korea.
2Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United States of America.
3Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
4Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
*Corresponding author: correspondence to Joonyeol Lee
†These authors contributed equally to this work
Abstract
Prior knowledge facilitates our perception and goal-directed behaviors, particularly when sensory input is lacking or noisy. However, the neural mechanisms underlying the improvement in sensorimotor behavior by prior expectations remain unknown. In this study, we examine the neural activity in the middle temporal (MT) area of visual cortex while monkeys perform a smooth pursuit eye movement task with prior expectation of the visual target’s motion direction. Prior expectations discriminately reduce the MT neural responses depending on their preferred directions, when the sensory evidence is weak. This response reduction effectively sharpens neural population direction tuning. Simulations with a realistic MT population demonstrate that sharpening the tuning can explain the biases and variabilities in smooth pursuit, suggesting that neural computations in the sensory area alone can underpin the integration of prior knowledge and sensory evidence. State-space analysis further supports this by revealing neural signals of prior expectations in the MT population activity that correlate with behavioral changes.
논문정보
- Research article
- 2023년 07월 (BRIC 등록일 2023-07-10)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 뇌인지과학
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
관련분야 논문보기
